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[cdn-nucl-l] Amelioration of Type II Diabetes by Continuous Low-Dose-Rate Irradiation; Fw: reprints
Folks,
I returned on Sunday from an International
Symposium on Radiation Hormesis (Nov 14-15) in Yokohama, Japan, where I
delivered two invited presentations (one on nuclear risk and one on therapeutic
applications). There was on-line audio translation to more than 700
enthusiastic delegates (at least half were women!). Dr. Kiyohiko Sakamoto
gave an excellent presentation on his research work on total (or half) body
low-dose irradiation and the TB-LDI therapies that he performed on some two
hundred cancer patients, more than ten years ago. Dr. Don Luckey
was there, and he stirred up even more excitement with his strong views about
our radiation deficiency.
There was another full day of lectures (no
translation) on Saturday Nov 17 at the Tokyo University with the
participation of about 100 physicians. I repeated my presentation on
therapeutic applications of radiation hormesis (using material from Jim
Muckerheide, Myron Pollycove, Ludwig Feinendegen, Kiyohiko Sakamoto and
Shu-Zheng Liu).
Japanese radiobiologists and medical scientists
continue to do remarkable research on beneficial health effects of low doses of
radiation or low dose-rate radiation. I just received a reprint (see
abstract below) of a recent publication on the beneficial effect of continuous
low-dose-rate radiation on Type II diabetes.
On Sunday morning, before going to the airport, we
visited a clinic in Tokyo. The clinic does mammograms and bone density
scans, but it also features a low-dose radiation spa with three sauna-like rooms
that are lined with monzanite---a thorium ore that emits radon and gamma
radiation. We entered one of the rooms, where the temperature is
maintained at 38 degC, and we measured the gamma-ray radiation field at the
ceiling. Guests stay in the rooms for an hour at a time. The spa
also serves glasses of radon water to drink. The place is very attractive;
we took many photos there.
Regards, Jerry
----------------------------------------------------
Amelioration of Type II Diabetes in db/db Mice by
Continuous Low-Dose-Rate Irradiation
Radiat. Res. 167, 592–599 (2007)
by Tsuruga, M., Taki, K., Ishii, G., Sasaki, Y.,
Furukawa, C., Sugihara, T., Nomura, T., Ochiai, A., and Magae,
J.
Low-dose-rate radiation modulates various
biological responses including carcinogenesis, immunological responses and
diabetes. We found that continuous irradiation with low-dose-rate rays
ameliorated type II diabetes in db/db mice, diabetic mice that lack leptin
receptors. Whole-body exposure of db/db mice to low dose-rate radiation improved
glucose clearance without affecting the response to insulin. Histological
studies suggested that degeneration of pancreatic islets was significantly
suppressed by the radiation. Insulin secretion in response to glucose loading
was increased significantly in the irradiated mice. These results suggest that
low-dose-rate radiation ameliorates type II diabetes by maintaining insulin
secretion, which gradually decreases during the progression of diabetes due to
degeneration of pancreatic islets. We also
inferred that protection from oxidative damage is involved in the anti-diabetic
effect of low-dose-rate rays because expression and activity of pancreatic
superoxide dismutase were significantly elevated by low-dose-rate
radiation.
2007 by Radiation Research
Society
----- Original Message -----
Sent: Monday, November 19, 2007 9:39
PM
Subject: reprints
> Dear Dr. Cuttler
>
> It was great pleasure for me to
have a chance to see you in Hormesis
> Symposium in Tokyo.
>
Attached and please find the reprints I published recently concerning
> ameliorative effect of LDR on diabetes, and a new model for dose
rate
> effect. I hope you have some interest in these
works.
>
> Sincerely
>
>
> Junji Magae
>
Radiation Safety Research Center
> Nuclear Technology Research
Laboratory
> Central Research Institute of
> Electric Power
Industry
>
> 2-11-1 Iwado Kita, Komae-shi
> Tokyo 201-8511
JAPAN
>
> TEL: +81-70-6556-7693
> FAX:
+81-3-3480-3113
> jmagae@criepi.denken.or.jp
>
>
>
>